Extracellular Vesicles in Skin Wound Healing

Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, which one the most promising is use extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such extensive involvement EVs suggests exploiting their action to modulate impaired phase. Furthermore, next natural capacity, can be engineered better defined pharmaceutical purposes, such as carrying specific cargo targeting destinations labelling them with certain surface proteins. This review aims promote scientific awareness basic translational research summarizing current knowledge about role each stage skin repair recent findings application areas, healing, regeneration, treatment dermal diseases, including stem cell-derived, plant-derived, EVs.